Resveratrol’s Antiaging, Brain-Boosting Potential By Dr. Diane Fulton for Natural Blaze
A natural polyphenol, resveratrol has the potential to bring you longevity and protection against brain diseases. Why not try this age-defying compound?
Resveratrol is a polyphenol naturally present in grape skins, berries, peanuts and red wine that possesses anti-inflammatory, neuroprotective[i] and antiaging properties.[ii] Foods rich in polyphenols like resveratrol protect against age-related diseases, such as cardiovascular disease,[iii] cancers,[iv],[v],[vi] arthritis,[vii] cataracts,[viii] osteoporosis,[ix],[x] Type 2 diabetes,[xi],[xii] high blood pressure,[xiii] pulmonary disease,[xiv] atherosclerosis[xv] and Alzheimer’s disease (AD).[xvi]
Resveratrol can influence multiple inflammatory and non-inflammatory responses, protecting organs and tissues, thanks to its interaction with immune cells and its activity on a protein called Sirtuin 1 (SIRT1), which is tied to inflammatory, metabolic and oxidative stressors.[xvii]
Resveratrol has been shown to mediate antiaging effects through modulation of many different pathways. It will bind to numerous cell-signaling molecules, activate various transcription factors, suppress the expression of antiapoptotic gene products, inhibit protein kinases, induce antioxidant enzymes, suppress the expression of inflammatory biomarkers, inhibit the expression of angiogenic and metastatic gene products and modulate cell cycle regulatory genes, which makes it a powerhouse against numerous age-associated diseases.[xviii]
Resveratrol and pterostilbene, the polyphenols found in grapes and blueberries, have beneficial effects as antiaging compounds through modulating the hallmarks of aging — oxidative damage, inflammation, telomere shortening and cell senescence. Both resveratrol and pterostilbene are linked to possible aging biomarkers — oxidative stress, inflammation and high-calorie diets — and have the potential to improve lifespan, prevent aged-related diseases and maintain health.[xix]
In a study of 125 postmenopausal women, aged 45 to 85 years, who took 75 milligrams (mg) of trans-resveratrol or placebo twice daily for 12 months and then crossed over to the alternative treatment for another 12 months, results show resveratrol has powerful antiaging and health effects.
Compared to placebo, resveratrol supplementation resulted in a 33% improvement in overall cognitive performance, and a relative improvement in verbal memory among women 65 and older was found, compared to those younger than 65 years. Regular supplementation with low-dose resveratrol showed positive impacts on cognition, cerebrovascular function and insulin sensitivity in postmenopausal women.[xx]
Using human skin tissue, researchers reported the presence of specific resveratrol binding sites in the epidermis of the skin. Exposure of these cells to the nitric oxide free radical donor sodium nitroprusside (SNP) resulted in cell death, which was significantly reduced by resveratrol at 14.7 micron (µM).