Glyphosate and Roundup: All Roads Lead to Cancer – New Study

Glyphosate and Roundup: All Roads Lead to Cancer – New Study by Sustainable Pulse

Glyphosate and Roundup lead to changes in gene regulatory microRNAs (miRNAs or miRs) linked with cancer, newly published data show. The analysis, of a type known as small RNA profiling, was conducted in liver tissue from rats exposed to glyphosate and Roundup MON 52276, an EU-approved formulation, over 90 days, GMWatch reported.

In the new results, Roundup MON 52276 was found to reduce the levels of miR-22 and miR-17, whereas glyphosate decreased the level of miR-30 and increased the amount of miR-10. These changes in miRNAs are important because they are known to alter the expression of crucial cell growth regulator genes, which can lead to the development of cancer.

A gene function that is central to multiple cellular processes, p53, is a particular target of these miRNAs. The miRNA changes can lead to alterations in p53 gene expression, as has been found in multiple types of cancer in humans.

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The link between the changes in miRNAs and p53 gene expression is consistent with the findings within the same study showing gene expression changes in Roundup- and glyphosate-exposed rats. The gene expression changes strongly imply a p53 pathway DNA damage response. DNA damage is a major risk factor for cancer development.

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Furthermore, increases in miR-10 have been found in other studies to be associated with leukemia, a blood cancer. The increase in mir-10 caused by glyphosate exposure in the experimental animals may provide one mechanism by which users of Roundup have succumbed to another blood cancer, known as non-Hodgkin lymphoma. These results could strengthen the legal cases of the cancer sufferers in the US who are suing Bayer/Monsanto because they believe that exposure to Roundup caused their disease. Three such cases have already been decided in favour of the plaintiffs.

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