Glyphosate and Roundup: All Roads Lead to Cancer – New Study by Sustainable Pulse
Glyphosate and Roundup lead to changes in gene regulatory microRNAs (miRNAs or miRs) linked with cancer, newly published data show. The analysis, of a type known as small RNA profiling, was conducted in liver tissue from rats exposed to glyphosate and Roundup MON 52276, an EU-approved formulation, over 90 days, GMWatch reported.
In the new results, Roundup MON 52276 was found to reduce the levels of miR-22 and miR-17, whereas glyphosate decreased the level of miR-30 and increased the amount of miR-10. These changes in miRNAs are important because they are known to alter the expression of crucial cell growth regulator genes, which can lead to the development of cancer.
A gene function that is central to multiple cellular processes, p53, is a particular target of these miRNAs. The miRNA changes can lead to alterations in p53 gene expression, as has been found in multiple types of cancer in humans.
The link between the changes in miRNAs and p53 gene expression is consistent with the findings within the same study showing gene expression changes in Roundup- and glyphosate-exposed rats. The gene expression changes strongly imply a p53 pathway DNA damage response. DNA damage is a major risk factor for cancer development.
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Furthermore, increases in miR-10 have been found in other studies to be associated with leukemia, a blood cancer. The increase in mir-10 caused by glyphosate exposure in the experimental animals may provide one mechanism by which users of Roundup have succumbed to another blood cancer, known as non-Hodgkin lymphoma. These results could strengthen the legal cases of the cancer sufferers in the US who are suing Bayer/Monsanto because they believe that exposure to Roundup caused their disease. Three such cases have already been decided in favour of the plaintiffs.
