Intermittent Fasting Diet Improves Health Without Altering The Body’s Core Clock from Natural Blaze
When it comes to metabolic health, it’s not just what you eat, it’s when you eat it. Studies have shown that one effective means of losing weight and tackling obesity is to reduce the number of hours in the day that you eat. Time-restricted feeding – otherwise known as intermittent fasting – has also been shown to improve health even before weight loss kicks in.
The biological explanation for the phenomenon remains poorly understood. So scientists from the University of Copenhagen, the Australian Catholic University and Karolinska Institutet investigated the body’s early adaptations to time-restricted feeding. Their study identified a number of key changes in the genetic activity of muscles, as well as the content of muscle fats and proteins, which could explain the positive impact of time-restricted feeding.
Novel insights on short-term time-restricted feeding
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The study is the first time scientists have examined the oscillations of metabolites in skeletal muscle and in blood, as well as gene expression in skeletal muscle after time-restricted feeding. By focusing on the short-term and early effects of time-restricted feeding, the goal was to disentangle the signals that govern health from those associated with weight loss.
“We observe that the rhythm of skeletal muscle core clock genes is unchanged by time-restricted feeding, suggesting that any differences are driven more by diet, rather than inherent rhythms,” says Postdoc Leonidas Lundell, from the Novo Nordisk Foundation Center for Basic Metabolic Research (CBMR) at the University of Copenhagen.
“We also see that the metabolite profile of skeletal muscle switches from being predominantly lipid based, to amino acid based, after time-restricted feeding. This coincides with changes in rhythmicity of amino acid transporters, indicating that part of the amino acid profile could be due to absorption from the blood.”
