Science Supports Reishi Mushrooms’ Health-Boosting Potential

Science Supports Reishi Mushrooms’ Health-Boosting Potential By: GreenMedInfo Research Group

Mushrooms are trending, and this fad has merits for your body, brain and even your spiritual well-being. See why reishis have earned the respect of the scientific community and learn how they can boost your health

The mushrooms commonly known as “reishi” are gaining deserved popularity for possessing near-magical gifts for the human body. Reishi (in Japanese) or ling zhi (靈芝 in Chinese) have been recognized as a medicinal mushroom for over 2,000 years, with their powerful effects noted in ancient texts, art, religion and even cultural artifacts.[i]

Traditionally ascribed such benefits as enhancing energy, strengthening the heart, increasing memory, tonifying the body and slowing aging, this rare and revered fungus has earned a reputation for being an “herb of spiritual potency.”[ii] Science has even validated reishi’s health-affirming properties, including an ability to control blood glucose levels, support the immune system, protect the liver and fight harmful bacterial infections.[iii]


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There are more than 200 scientific abstracts on GreenMedInfo.com with evidence of reishi mushroom’s disease fighting properties. In this article, we break down the science that supports reishi’s health-boosting potential in three key areas: cancer prevention, heart health and enhanced immunity to viruses.

Reishi’s Cancer-Fighting Reputation

Reishi mushrooms have been clinically shown to fight a triad of risks — aging, disease and cancer, thanks to a superlative power: the ability to isolate, digest and flush toxins from the body.[iv] This detox support increases the liver’s metabolic efficiency, which can aid the body in disease prevention. Studies on reishi have confirmed that these mushrooms exhibit “significant potency to prevent and treat different types of cancers,” including breast, prostate, colon, lung and cervical.[v]

A 2020 metastudy explored the anticancer effects of various pharmacologically active compounds in reishis — species name Ganoderma lucidum — and their potential modes of action. Evidence was found for a variety of diverse anticancer mechanisms, including modulating the immune system, increasing the metabolic rate of enzyme activity and being toxic to cancer cells, thereby suppressing the expression of proteins required for cancer cell reproduction.[vi]

An article published in the journal Seminars in Cancer Biology summarized progress made in treating metastatic cancer, a form that spreads and migrates within the body, by saying that reishis and other medicinal mushrooms contain cancer-inhibiting compounds that are “useful approaches to target tissue invasion and metastasis as well as other hallmark areas of cancer.”[vii] 

An array of studies have ascribed antitumor, antioxidant, blood balancing and unique detoxification properties to G. lucidum and recommended it as an adjunct therapy for cancer treatment. There are even clinical drugs extant today that are derived from polysaccharides and beta-glucans extracted from reishi and other medicinal mushrooms.[viii]

Heart Healthy Reishi Mushrooms

Atherosclerosis is a chronic inflammatory disease characterized by the buildup of plaque in the arterial walls of the cardiovascular system, which can cause blood clots leading to heart attack or stroke. In the U.S., 1 in 4 deaths are due to heart disease,[ix] although atherosclerosis can also affect the brain.

The beta-glucan found in reishi mushrooms has potent antioxidant properties that may guard against atherosclerosis in high-risk patients.[x] Another isolate that has been extracted from G. lucidum mushrooms are polysaccharide peptides (PsP), protein-bound carbohydrate cells that, along with beta-glucans, have been identified as active compounds in reishi mushrooms. PsP, a powerful antioxidant, has been clinically shown to prevent atherogenesis, the formation of fatty plaques in the arteries, in mice models.[xi]

Another way reishis may help protect your heart is by ameliorating the negative effects of the standard American diet. In a 2016 study, researchers observed that a beta-glucans extract derived from reishi mushrooms reduced the inflammation response in mice being fed an unhealthy diet.[xii]

Reishi’s Antiviral Superpowers

Significant evidence backs reishis’ demonstrated potential for keeping your body in a state of health and balance, including helping you fight off viral infections. Reishis have been tested for effects on herpes simplex viruses 1 and 2, known as HSV-1 and HSV-2, or oral and genital herpes, respectively.

A study published in the Journal of Alternative and Complementary Medicine demonstrated that individuals diagnosed with HSV-2 who had experienced recurrent herpes outbreaks for more than one year were aided by an herbal mixture of two powdered reishi-type mushrooms (Ganoderma lucidum, Elfuinga applanata). Results were dramatic: the mix of mushrooms and herbs provided “fast, effective relief from symptoms of recurrent herpes [outbreaks],” with a decrease in symptomatic time of more than 50% compared to controls.[xiii]

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